Seeking the thermodynamic limit of biomanufacturing
One question in — a dossier you can audit.
✓ Opening Kairos with your question…
A deterministic review layer audits every claim — PASS / WARN / FAIL.
Numbers we publish — and re-run
Deterministic designs, cited evidence — recent work from the Evolrix AI team.
One question in — a dossier you can audit.
A Kairos session ends as a workbench dossier: cited evidence, a ranked design panel, structure checks, and a claim-by-claim audit.
Provenance, not persuasion.
An AI company building the tools that make synthetic biology computable — dramatically accelerating the path from research question to manufacturing-ready design.
What a Kairos session actually returns
Two live captures from the workbench, on a user-provided Q6Q4H8 sequence — the ranked design panel and the claim-by-claim audit. Nothing staged.
Every claim traces to something you can open.
Sources PubMed NCBI AlphaFold DB Boltz-2 patents curated knowledge graph
Every number re-runnable — see the benchmarks → host-fidelity reward vs measured titers, retrospective
Recent dossiers
Anatomy of a Kairos dossier
What is actually inside a dossier, and where each part comes from.
limitsThe thermodynamic limit of biomanufacturing
Why some designs cannot hold up mathematically, no matter how they are built.
designSecretion construct design
The full reasoning chain, from signal peptide to manufacturability panel.
From question to design — one dry-lab loop
Multi-step reasoning you can inspect, challenge, and cite.
Evidence synthesized with provenance across the literature and a knowledge graph.
A deterministic review layer audits every claim — PASS / WARN / FAIL.
What Kairos does
- Ranks synthesis safety & host resemblance for Pichia constructs
- Optimizes expression-construct elements — learned effects matching known biology (pCS1, ERO1/SBH1)
- Scores 5′ translation initiation & protein developability
- Checks structures in silico — AlphaFold DB + Boltz-2 confidence
- Cites every claim to literature you can open and check
- Audits every claim — automated PASS / WARN / FAIL verdict, line by line
- Scores downstream manufacturability — fermentation, DSP recovery & directional cost, every number cited
Pichia-optimized dry-lab design, end to end — from cited evidence to an audited, order-ready construct. Bench validation runs through our partner network. Full scope statement →
What teams ask
What is Evolrix AI?
An AI company building the tools that make synthetic biology computable — dramatically accelerating the path from research question to manufacturing-ready design. Designs that are provably correct, scores you can re-run, and answers grounded in literature. Built for teams that need provenance, not persuasion.
Who is it for?
Industrial R&D teams in synthetic biology, metabolic engineering, and biotech — from early-stage design to pre-manufacturing validation.
What can it do today?
Kairos v0.19.6 (Pichia-scoped): conversational research with cited evidence retrieval, LLM-backed reasoning, ranked CDS design panels with host-fidelity scores and expression-construct optimization (element effects matching known biology (pCS1, ERO1/SBH1)), secretion leader design, a downstream manufacturability panel (fermentation, DSP sequence, step-wise recovery, directional cost — every number cited), hypothesis-driven verification where every hypothesis receives a supported / contested / unverified / insufficient verdict, and an automated review layer that audits every claim with a PASS / WARN / FAIL verdict and also assesses whether each cited source actually supports the claim (same organism, same target, entailed or contradicted). Expanding to more hosts.
How does the chat work?
Ask a research question in natural language. Small talk gets an instant answer; quick questions get a fast cited reply; research questions go straight into the full pipeline. Kairos retrieves cited evidence, reasons with an LLM, runs deterministic design tools, and streams the result into a multi-panel workbench — evidence, design, structure, manufacturability, audit — with a 1–2 screen summary right in the chat and a deduplicated provenance manifest (PMID / DOI / patent / knowledge graph) under Generated Files. Each section carries its provenance, and the audit panel shows a claim-by-claim PASS / WARN / FAIL verdict.
What is Kairos scoped to?
Kairos ranks dry-lab design quality — synthesis safety, host resemblance, expression-construct optimization, 5′ translation initiation, and protein developability. Expression and titer are wet-lab questions, answered by wet-lab data.
Bring a target protein. Leave with a ranked design panel
Kairos ranks dry-lab design quality. Expression and titer are wet-lab questions, answered by wet-lab data.